Lab Test Glossary J

Jo-1 ig Antibody: The presence of antibodies against the Jo-1 antigen occurs in various autoimmune inflammatory conditions, including myositis, interstitial lung disease, and arthritis conditions. Antibodies against the Jo-1 antigen are found in about 30% of adult patients with myositis and are particularly common in patients with both myositis and interstitial lung disease. Jo-1 antibodies are most often found in patients with the antisynthetase syndrome, which is characterized by an acute onset, steroid-responsive myositis with interstitial lung disease, fever, symmetrical arthritis, Raynaud’s phenomenon, and “mechanic’s hands”.
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