Lab test glossary U

Lab Test Glossary U

Uric Acid: Uric acid is the end product of purine metabolism. Purines are obtained from both dietary sources and from the breakdown of body proteins. Most uric acid produced in the body is excreted by the kidneys. An overproduction of uric acid occurs when there is excessive breakdown of cells, which contain purines, or an inability of the kidneys to excrete uric acid. Uric acid elevations may occur in gout, kidney disease with kidney failure, dehydration, diuretic use, alcoholism, lead poisoning, lymphoma, leukemia, infectious mononucleosis, acute inflammatory state, acidosis, hyperparathyroidism, hypothyroidism, sarcoidosis, toxemia of pregnancy, chemotherapy and radiation therapy. Causes of low uric acid levels include renal tubular defects, liver disease, Wilson’s disease (excessive levels of copper), hemochromatosis (excessive levels of iron), syndrome of inappropriate secretion of antidiuretic hormone (SIADH) which causes large amounts of fluid to build up in the body, and the use of certain drugs.
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